Ketamine Connections

Episode 53 | What If the Ketamine Stops Working?

Anna Krishtal

Relief, rewiring, and why the real work is never done.

Have you ever wondered if it’s okay to go back for another ketamine session, even if you’re no longer in crisis? Are you afraid that your relief is fading and that something went “wrong”? Or maybe you’re asking the big question: Did the ketamine even work if it didn’t last?

In this powerful listener-inspired episode, Anna answers a nuanced and common question:

“Is it okay to return to ketamine even if my depression is under control?”

This episode breaks down what it really means when ketamine “stops working,” and what you can do to deepen, sustain, and build on the relief you’ve already experienced.

You’ll learn:

  • Why some people feel better after 1 session, while others need 6+
  • The difference between temporary relief and lasting change
  • What upregulated neuroplasticity really means (and how long it lasts)
  • The psychedelic model of healing vs. the psychiatric model
  • How contrast (even fleeting lightness) is actually a crucial breakthrough
  • Why wanting a ketamine booster isn’t “abuse” and how to decide if it’s right for you
  • What it means to heal in layers, and how to know when you’re ready for the next one
  • Why preparation + integration are what make the ketamine experience transformational

✨ Plus: Anna shares personal stories of moving from white-knuckle survival to joyful permission, and reclaims the radical truth that feeling good is a legitimate reason.

🔗 Resources & Links

📘 Referenced Episodes:

🧠 Explore the Ketamine Preparation Protocol (KPP):
Ready to prepare deeply, or return to the medicine with clarity? KPP is for you.
→ Join the Ketamine Preparation Protocol: https://www.annakrishtal.com/kpp

📖 Book Mentioned:

  • Drug Use for Grown-Ups by Dr. Carl Hart